Risk factors associated with mortality in critically ill patients with SARS-CoV-2 pneumonia in a tertiary hospital in Ecuador
Autores/as
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Fausto Guerrero-Toapanta
Universidad de Las Américas (UDLA). Ecuador
https://orcid.org/0000-0002-5839-8539
- Jorge Hurtado-Tapia Hospital de Especialidades Carlos Andrade Marín . Ecuador
- Abel Godoy-Miketta Hospital de Especialidades Carlos Andrade Marín . Ecuador
- Yeimi Herrera-Parra Hospital de Especialidades Carlos Andrade Marín . Ecuador
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Freddy Maldonado-Cando
Hospital de Especialidades Carlos Andrade Marín . Ecuador
https://orcid.org/0000-0001-8335-7969
- Gabriel García-Montalvo Hospital de Especialidades Carlos Andrade Marín . Ecuador
- José Vinueza-Rivadeneira Hospital de Especialidades Carlos Andrade Marín . Ecuador
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Juan López-Altamirano
Hospital de Especialidades Carlos Andrade Marín . Ecuador
https://orcid.org/0000-0003-4936-6022
- Edison Ramos-Tituaña Hospital de Especialidades Carlos Andrade Marín . Ecuador
- Cecilia Cruz-Betancourt Hospital de Especialidades Carlos Andrade Marín . Ecuador
DOI:
https://doi.org/10.70099/BJ/2026.03.01.11Palabras clave:
Pneumonia, Viral Pneumonia, SARS-CoV-2, COVID-19, Sepsis, Adult Respiratory Distress Syndrome, Critical Care, Mechanical Ventilation.Resumen
Objectives: SARS-CoV-2 pneumonia in critically ill patients is characterized by a high mortality rate. Numerous risk factors have been identified for this condition. The objective of this study was to determine the risk factors for mortality in critically ill patients with SARS-CoV-2 pneumonia receiving invasive mechanical ventilation.
Methods: This was an observational and retrospective study of patients who were in the intensive care unit of a third-level hospital between March 2020 and September 2021. Adults with confirmed SARS-CoV-2 infection and who were in the unit for more than 48 hours were included. Demographic, clinical, laboratory, and mechanical ventilation data were collected. All patients received protocolized treatments. Univariate and multivariate analyses were performed, with a p value of < 0.05, and the R statistical tool was used.
Results: Of 1024 patients, 203 were analyzed. In the univariate analysis, the age, weight, hypertension status, Simplified Acute Physiology Score III, Charlson Comorbidity Index score, neutrophil/lymphocyte ratio and acute respiratory distress syndrome status significantly differed between the living and deceased patients groups. In the multivariate analysis, the Charlson Comorbidity Index score (OR 1.36, 95% CI 1.12-1.68, p=0.002), acute respiratory distress syndrome (OR 4.16, 95% CI 1.24-16.04, p=0.02), and neutrophil/lymphocyte ratio (OR 1.040, 95% CI 1.00-1.07, p= 0.02) remained statistically significant. The mortality rate in the unit was 58.1%.
Conclusions: The Charlson Comorbidity Index score, neutrophil/lymphocyte ratio and acute respiratory distress syndrome status were associated with increased mortality.
Citas
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Derechos de autor 2026 FAUSTO GUERRERO-TOAPANTA, Jorge Hurtado-Tapia, Abel Godoy-Miketta, Yeimi Herrera-Parra, Freddy Maldonado-Cando, Gabriel García-Montalvo, José Vinueza-Rivadeneira, Juan López-Altamirano, Edison Ramos-Tituaña, Cecilia Cruz-Betancourt (Author)
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