Terminological Rigor in Nanomedicine: Standardizing 'Nano' Descriptors for Reproducibility and Translational Success
Autores/as
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Hortensia Rodriguez
achay Tech Medicinal Chemistry Research Group (MedChem-YT), School of Chemical Science, Yachay University for Experimental Technology and Research (Yachay Tech), Yachay City of Knowledge, Urcuqui 100119, Ecuador
https://orcid.org/0000-0001-6910-5685
DOI:
https://doi.org/10.70099/BJ/2025.02.02.1Palabras clave:
nanomedicine, terminology standardization, drug delivery systems, scientific rigor, nanocarriers, size characterization, stimuli-responsive systems, targeted delivery, regulatory reproducibility, translational nanotechnology, EPR effect, nanoparticle characterization, academic integrityResumen
The rapid growth of nanomedicine has revolutionized drug delivery innovations. Nevertheless, the scientific credibility is jeopardized by the uncritical use of "nano" terminology, which is frequently lacking in robust physicochemical or functional validation. This editorial denounces the misuse of terms such as "targeted delivery," "smart carriers," and "nanoparticles," which are frequently employed without experimental justification. We recommend concrete measures to standardize terminology, encouraging authors, journal editors, and educators to implement evidence-based definitions. To guarantee reproducibility, regulatory transparency, and successful clinical translation in nanomedicine, it is imperative to achieve rigorous semantic precision.
Citas
Park K. Facing the Truth about Nanotechnology in Drug Delivery. ACS Nano. 2013;7:7442–7447. doi:10.1021/NN404501G
Wilhelm S, Tavares AJ, Dai Q, et al. Analysis of nanoparticle delivery to tumours. Nat Rev Mater. 2016;1(5):16014. doi:10.1038/natrevmats.2016.14
Öztürk K, Kaplan M, Çalış S. Effects of Nanoparticle Size, Shape, and Zeta Potential on Drug Delivery. Int J Pharm. 2024;666:124799. doi:10.1016/J.IJPHARM.2024.124799
Xia S, Duan Y, Yu S, et al. A Cellulosic Multi-Bands Fluorescence Probe for Rapid Detection of PH and Glutathione. Carbohydr Polym. 2024;331:121893. doi:10.1016/J.CARBPOL.2024.121893
Ramos TI, Villacis-Aguirre CA, Sandoval FS, Martin-Solano S, Manrique-Suárez V, Rodríguez H, Santiago-Padilla L, Debut A, Gómez-Gaete C, Arias MT, et al. Multilayer Nanocarrier for the Codelivery of Interferons: A Promising Strategy for Biocompatible and Long-Acting Antiviral Treatment. Pharmaceutics. 2024; 16(11):1349. https://doi.org/10.3390/pharmaceutics16111349
Talele P, Jadhav A, Sahu S, Shimpi N. Experimental Approaches to Evaluate Solid Lipid Nanoparticle-Based Drug Delivery Systems. Anal Methods. 2025;17:1451–1466. doi:10.1039/D4AY01659A
Shreyash N, Sonker M, Bajpai S, Tiwary SK. Review of the Mechanism of Nanocarriers and Technological Developments in the Field of Nanoparticles for Applications in Cancer Theragnostics. ACS Appl Bio Mater. 2021;4:2307–2334. doi:10.1021/ACSABM.1C00020
Ruiz, A.; Suárez, M.; Mar
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