Exosomal Load: Biomarkers in Cancer Diagnosis
Autores/as
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Gabriela Campoverde Ortega
Universidad Técnica de Ambato, Facultad de Ciencias de la Salud, carrera de Laboratorio Clínico, Ambato - Ecuador
https://orcid.org/0009-0007-0422-0288
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Elizabeth Proaño-Pérez
Universidad Técnica de Ambato, Facultad de Ciencias de la Salud, carrera de Laboratorio Clínico, Ambato - Ecuador
https://orcid.org/0000-0002-0185-3414
DOI:
https://doi.org/10.70099/BJ/2025.02.01.12Palabras clave:
Exosomes, Tumor Biomarkers, Cancer, Clinical DiagnosisResumen
Cancer is a global health problem, and one of its main challenges is timely detection. Therefore, the determination of exosomal biomarkers has been proposed as a possible tool when diagnosing this pathology. In addition to being important elements in intracellular communication by transporting cellular biomolecules such as lipids, nucleic acids, proteins, and metabolites associated with their producer cell, they act as main regulators of the tumor microenvironment, responsible for angiogenesis, progression, and development of metastasis. For their isolation, there are various techniques related to ultracentrifugation, ultrafiltration, and immunoaffinity that allow their separation from different sources, whether biological fluids or culture media, facilitating their study in the context of cancer.
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