High Prevalence of Neurological Complications in Pediatric Chronic Kidney Disease: A Cross-Sectional Study from Honduras
DOI:
https://doi.org/10.70099/BJ/2025.02.02.14Palabras clave:
Uremic neuropathy, cognitive impairment, pediatric chronic kidney disease, neurological complications, Honduras,, pediatric nephrologyResumen
Chronic kidney disease (CKD) in children has a global incidence of 32.4 cases per million, with neurological manifestations (NM) significantly contributing to morbidity. In Latin America, few studies address these complications. This cross-sectional study assessed NM frequency in 59 pediatric CKD patients (stages I-V) at Hospital María, Pediatric Specialties (HMEP), Honduras. Hospitalized patients, transplant recipients, and those with incomplete data were excluded. The mean age was 12 (SD: 4.2), with male predominance (62.7%). NMs were present in 71.2% of cases, primarily affecting the central nervous system (CNS) (69%), followed by combined CNS-PNS (23.8%) and peripheral nervous system (PNS) (7.1%). Stage V CKD showed the highest NM frequency (66.7%). These findings highlight the high prevalence of neurological complications in children with CKD, especially in advanced stages, underscoring the need for systematic neurological screening in this population. Despite sample size limitations, this study provides valuable evidence for low-resource settings.
Citas
1. Safdar O, Sindi S, Nazer N, Milyani A, Makki A. Neurological complications and associated risk factors in children affected with chronic kidney disease. Children (Basel). 2020;7(6):59.
2. Abd El Naby SA, Bahbah WA, Kasemy ZA, Mahmoud AA. Neurophysiological and neuroradiological changes in children with chronic kidney disease. Front Pediatr. 2020;8:570708.
3. Gómez-Morejón A, Pérez-González L, Chaviano-Mendoza O, González-Ramos J, Yanes-Macías J, Quintana-Marrero A. La prevención del daño renal crónico: una prioridad desde la niñez. Rev Finlay. 2021;11(1):e31.
4. Guerra A, Dobras B. Características clínicas, epidemiológicas y evolución de pacientes con enfermedad renal crónica estadio 5, del año 2005 al 2015 en el Hospital de Especialidades Pediátricas Omar Torrijos H. Panamá. Rev Méd Panamá. 2018;38(1):8.
5. Vellanki K, Bansal VK. Neurologic complications of chronic kidney disease. Curr Neurol Neurosci Rep. 2015;15(8):50.Europe PMC+1PubMed+1
6. Uwaezuoke SN, Ayuk AC, Muoneke VU, Mbanefo NR. Chronic kidney disease in children: using novel biomarkers as predictors of disease. Saudi J Kidney Dis Transpl. 2018;29(4):775–84.
7. Hamed SA. Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies. Expert Rev Clin Pharmacol. 2019;12(1):61–90.
8. Martínez DF, Fumero RTA, Levis ON, Anzorandia CS, Moliner RB. Conducción nerviosa en niños con insuficiencia renal crónica. Rev Cubana Pediatr. 2002;74(2):115–21.
9. Afsharkhas L, Hoseininajad N, Kalbassi Z. Neurologic manifestations in children and adolescents with chronic kidney diseases. Iran J Child Neurol. 2015;9(2):16–9.
10. Albaramki JH, Al-Ammouri IA, Akl KF. Neurological and cardiac complications in a cohort of children with end-stage renal disease. Saudi J Kidney Dis Transpl. 2016;27(3):507–11.
11. Torales J, Florentín L, Rolón-Méndez E, Gutiérrez G, Sánchez García de Zúñiga M, et al. Trastornos mentales en niños y adolescentes con enfermedad renal crónica: un primer estudio de detección realizado en Paraguay. Rev Nac (Itauguá). 2024;16(2):1–14.
12. Galeas M. Caracterización de la enfermedad renal crónica terminal en pediatría del Hospital Mario Catarino Rivas. [Tesis de licenciatura]. San Pedro Sula: Universidad Nacional Autónoma de Honduras; 2018.
13. Harada R, Hamasaki Y, Okuda Y, Hamada R, Ishikura K. Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies. Pediatr Nephrol. 2022;37(6):1215–29.
14. Ataei N, Madani A, Esfahani ST, Otoukesh H, Hooman N, Hoseini R, et al. Chronic kidney disease in Iran: first report of the national registry in children and adolescents. Urol J. 2021;18(1):122–30.
15. Stabouli S, Gidaris D, Printza N, Dotis J, Papadimitriou E, Chrysaidou K, et al. Sleep disorders and executive function in children and adolescents with chronic kidney disease. Sleep Med. 2019;55:33–9.
16. Balat A. Children with chronic kidney disease and hypertension: could hypertension footprints be early biomarkers? Curr Hypertens Rev. 2014;10(2):86–98.
17. Amanullah F, Malik AA, Zaidi Z. Chronic kidney disease causes and outcomes in children: perspective from a LMIC setting. PLoS One. 2022;17(6):e0269632.
18. Çelakıl M, Çoban Y. Etiologic-sociodemographic assessment and comparison of dialysis modalities in pediatric Syrian migrants with chronic kidney disease. J Bras Nefrol. 2022;44(1):68–74.
19. Fang C, Lau WL, Sun J, Chang R, Vallejo A, Lee D, et al. Chronic kidney disease promotes cerebral microhemorrhage formation. J Neuroinflammation. 2023;20(1):51.
20. Baluarte JH. Neurological complications of renal disease. Semin Pediatr Neurol. 2017;24(1):25–32.
21. Shieh A, Darro N. Recurrent posterior reversible encephalopathy syndrome in an adolescent boy with end-stage renal disease. Case Rep Pediatr. 2021;2021:6675454.
22. Wijaya EA, Solek P, Hakim DDL, Rossanti R, Widiasta A, Hilmanto D. Factors affecting neurocognitive function in children with chronic kidney disease: a systematic review. Int J Nephrol Renovasc Dis. 2022;15:277–88.
23. Ruebner RL, Laney N, Kim JY, Hartung EA, Hooper SR, Radcliffe J, et al. Neurocognitive dysfunction in children, adolescents, and young adults with CKD. Am J Kidney Dis. 2016;67(4):567–75.
24. Afsharkhas L, Hoseiny Nejad N, Kalbassi Z. Neurologic manifestations in children and adolescents with chronic kidney diseases. Iran J Child Neurol. 2015;9(2):16–19.
25. Sonbhadra A, Reddy BVC, Saini AG, Tiewsoh K, Paria P, Kesavan S, et al. Peripheral neuropathy in children with chronic kidney disease: are we looking enough? Ann Indian Acad Neurol. 2022;25(3):389–93.
26. Yoganathan S, Bagga A, Gulati S, Toteja GS, Hari P, Sinha A, et al. Prevalence and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease. Muscle Nerve. 2018;57(5):792–8.
27. Mohammadi MH, Salarzaei M, Parooie F. Neurological complications after renal transplantation: a systematic review and meta-analysis. Ther Apher Dial. 2019;23(6):518–28.
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