Risk of renal dysfunction in patients with dengue fever: a case-control study
Autores/as
-
Kaleem Maqsood
Institute of Zoology, University of the Punjab, Lahore; Pakistan
https://orcid.org/0000-0003-2330-3162
DOI:
https://doi.org/10.70099/BJ/2024.01.04.12Palabras clave:
electrolytes, renal profile, dengue fever, severe dengue feverResumen
Dengue fever, a mosquito-borne infection, is typically caused by the Dengue virus, leading to various illnesses, including dengue fever and severe dengue fever. This study aims to investigate the outcome of dengue fever severity as renal dysfunction in patients. For this case-control study, blood samples of the patients (N=66), including 31 D-W (Dengue without warning signs), 20 D+W (Dengue with warning signs), and 15 SDF (Severe dengue fever), as well as controls (N=45) of same age groups, were obtained. The renal parameters were determined and statistically analyzed using a one-way ANOVA and chi-square/Fisher exact test. The intergroup comparison showed that phosphorous, calcium, and sodium presented a marked decrease (P < 0.001) in dengue patient groups compared to controls. However, a significant increase (P < 0.05) in chloride was indicated in dengue patient groups. Moreover, a prominent potassium reduction (P = 0.036) was observed in the dengue subjects group compared to controls. Among the renal parameters, creatinine presented a significant elevation (P < 0.002) while uric acid was significantly (P = 0.004) dropped in dengue patients groups as compared to controls. This study's results suggest that dengue infection's severity may be associated with aberrant electrolyte imbalance and renal impairment. This study indicates that dengue affects normal kidney functions and harms the patients' health.Citas
1. Arora M, Patil RS. Cardiac manifestation in dengue fever. J Assoc Physicians India. 2016;64(7):40-4.
2. Araújo SA, Moreira DR, Veloso JMR, Silva JO, Barros VLSR, Nobre V. Case report: fatal staphylococcal infection following classic dengue fever. The American journal of tropical medicine and hygiene. 2010;83(3):679.
3. WHO. Dengue fever – Pakistan: World Health Organization; 2021 [updated December 14 2021. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/dengue-fever-pakistan.
4. Schaefer TJ, Panda PK, Wolford RW. Dengue fever. 2017.
5. Waterman SH, Gubler DJ. Dengue fever. Clinics in dermatology. 1989;7(1):117-22.
6. Halstead SB. Pathophysiology and pathogenesis of dengue haemorrhagic fever. Monograph on dengue/dengue haemorrhagic fever New Delhi: World Health Organization. 1993:80-103.
7. Ochei JO, Kolhatkar AA. Medical laboratory science: theory and practice: McGraw Hill Education; 2000.
8. Schöttker B, Brenner H, Koenig W, Müller H, Rothenbacher D. Prognostic association of HbA1c and fasting plasma glucose with reduced kidney function in subjects with and without diabetes mellitus. Results from a population-based cohort study from Germany. Preventive medicine. 2013;57(5):596-600.
9. Hakovirta H, Syed V, Jégou B, Parvinen M. Function of interleukin-6 as an inhibitor of meiotic DNA synthesis in the rat seminiferous epithelium. Molecular and cellular endocrinology. 1995;108(1-2):193-8.
10. Gurugama P, Jayarajah U, Wanigasuriya K, Wijewickrama A, Perera J, Seneviratne SL. Renal manifestations of dengue virus infections. Journal of Clinical Virology. 2018;101:1-6.
11. Mallhi TH, Khan YH, Adnan AS, Tanveer N, Aftab RA. Dengue-Induced Renal Complications. Expanded Dengue Syndrome: Springer; 2021. p. 35-54.
12. Mekmullica J, Suwanphatra A, Thienpaitoon H, Chansongsakul T, Cherdkiatkul T, Pancharoen C, et al. Serum and urine sodium levels in dengue patients. Southeast Asian J Trop Med Public Health. 2005;36(1):197-9.
13. Patil VC, Botre A, Patil R. Study of Electrolyte Disturbances in Dengue Infected Patients. 2019.
14. Anwar T, Rais H, Saba Safdar SE. Altered Electrolyte Homeostasis and the Severity of Dengue in Children.
15. Hira HS, Kaur A, Shukla A. Acute neuromuscular weakness associated with dengue infection. Journal of neurosciences in rural practice. 2012;3(01):36-9.
16. Kelly A, Levine MA. Hypocalcemia in the critically ill patient. Journal of intensive care medicine. 2013;28(3):166-77.
17. Singh AR, Dnyanesh D. The prevalence of hypocalcemia in children with dengue infection: A 1-year cross-sectional study. Indian Journal of Health Sciences and Biomedical Research (KLEU). 2019;12(2):166.
18. Halevy J, Bulvik S. Severe hypophosphatemia in hospitalized patients. Archives of Internal Medicine. 1988;148(1):153-5.
19. Jha S, Ansari M. Dengue infection causing acute hypokalemic quadriparesis. Neurology India. 2010;58(4):592.
20. Ismail J, Sankar J. Acute Kidney Injury in Dengue–Not Unprecedented. The Indian Journal of Pediatrics. 2020;87(12):993-4.
21. Haschek W, Winder C. Occupational toxicology of the kidney. Occupational toxicology: CRC Press; 2004. p. 153-67.
22. Hasannia T, Moosavi Movahed SM, Vakili R, Rafatpanah H, Hekmat R, Valizadeh N, et al. Active CMV and EBV infections in renal transplant recipients with unexplained fever and elevated serum creatinine. Renal Failure. 2016;38(9):1418-24.
23. Akomolafe R, Adeoshun I, Fakunle JB, Iwalewa E, Ayoka A, Ajayi O, et al. Changes in some biochemical parameters of kidney functions of Plasmodium berghei infected rats administered with some doses of artemether. African Journal of Biotechnology. 2012;11(27):7119-27.
24. Mehboob R, Syed AS, Bukhari MH, Khan AA, Ahmad FJ. Predictors for severity of dengue infection during early days of infection. Walailak Journal of Science and Technology (WJST). 2012;9(4):369-74.
25. Cui L, Pang J, Lee YH, Ooi EE, Ong CN, Leo YS, et al. Serum metabolome changes in adult patients with severe dengue in the critical and recovery phases of dengue infection. PLoS neglected tropical diseases. 2018;12(1):e0006217.
Descargas
Publicado
Cómo citar
Número
Sección
Categorías
Licencia
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Authors who publish with BioNatura Journal agree to the following terms: Authors retain copyright and grant the BioNatura Institutional Publishing Consortium (BIPC) right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). This allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
