Topical antifungal cream made with the hydroalcoholic extract from the endemic species Piper ecuadorense Sodiro (matico)
DOI:
https://doi.org/10.70099/BJ/2024.01.04.11Keywords:
Topic cream, hydroalcoholic extract, Piper ecuadorense, antifungal activityAbstract
The present study describes the process of a technological adaptation performed at the laboratory level to prepare a topic cream with antifungal activity using the alcoholic extract (70%) of the endemic Piper ecuadorense Sodiro (Matico) species. During processing, the behavior of semisolid formulations (creams) was evaluated in terms of organoleptic and physicochemical characteristics and in vitro antifungal activity of the cream at three different storage temperature conditions: (i) Environment, (ii) 30 °C ± 2, and (iii) 45 °C ± 2 for three months. Properties such as aspect, texture, density, pH, and extensibility were considered to determine each cream's stability. According to the dosage of the ethanolic extract to inhibit fungal growth, the cream made using 1% of the extract turned out to be the most effective formulation, so it gave a positive response against the two dermatophytes to which it was exposed, Trichophyton mentagrophytes ATCC® 28185 and Trichophyton rubrum ATCC® 28188 according to a dosage of 1000 µg/mL during one month of evaluation. Due to promising antifungal results, the developed formula could be used in further studies to evaluate its clinical efficiency in treating topical skin conditions.
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